Ua manaʻo lōʻihi ʻia ka salamander ahi i nā holoholona he nui a me nā mea weliweli. Ma kahi o ka manaʻo pālahalaha nui e hiki iā ia ke noho i ke ahi me ka hōʻeha ʻole iā ia iho, ua ʻike ʻia nō hoʻi kona ʻano momona. ʻO Pliny the Elder (23-79 AD) i kākau ai: "ʻO ka weliweli loa o nā holoholona āpau ko ka salamander. ʻO nā poʻe ʻē aʻe e ʻāʻī aku i ka liʻiliʻi a make loa kekahi. He hiki ʻole i ka salamander ke luku aku i ka ʻāina holoʻokoʻa i ʻike ʻole kekahi. A inā piʻi ka salamander i kahi lāʻau, lilo nā hua a pau ma laila. Inā pili ke salamander i ka lau i ka moʻo ʻana o ka berena, a laila ua lilo ka berena, ua hāʻule i ka kahawai, hoʻoilo ʻo ia i ka wai (hoihoi, iho wale ana i lalo, a ʻoi aku paha. Eia nō hoʻi? :) Kūkākahi Bufo-do.) Inā pili ʻo ia i kekahi wahi o ke kino, kūʻai ka lauoho o ka manamana lima, hāʻule nā ​​lauoho o ke kino a pau. Akā, ʻo kekahi mau holoholona, ​​e like me ka puaʻa, ʻai i kēia holoholona weliweli, no ka mea he ʻenemi mākou. "
I ka hoʻomaikaʻi ʻana iā Pliny (ʻoiai hikiʻole iā ia ke hōʻole ʻia i kekahi o kāna mau postulat), e noʻonoʻo mākou no ke ʻano o ka holoholona weliweli i kēia manawa, i ka wā i lawe ai nā mea noiʻi, ʻaʻole makaʻu me ka neʻe o ka lauoho a pau ma ke kino.

I kēia manawa i loaʻa mai ai i ka 1860, ua ʻike ʻia ka alkaloids ke ʻano ikaika o ka loea salamander, a ma ka 1930 ua hoʻoholo ko lākou ʻano. He mea pōmaikaʻi nā mea noiʻi a me nā salamanders, loaʻa nā nui o ka alkaloid i loaʻa i nā kelepa parotid o kēia mau amphibia, ʻaʻole like, no ka hoʻohālike ʻana i ka lāʻau piʻi lāʻau (Dendrobates), i kākau mākou e pili ana i kā mākou ʻatikala mua). Ua kapa ʻia ka alkaloid nui ma samandarin, a ua hoʻohālikelike ʻia ka 9 mau alkaloids me nā ʻano like ʻole. ʻO ka maʻamau o ka hapa nui o nā samandarin alkaloids ka loaʻa ʻana o ke apo oxazolidine.

He make poʻona ʻo Samandarin, ʻo kona lethal dosis no ke kiʻi he 70 mcg. No loko o ka pūʻulu o nā neurotoxins a hoʻoilo i ka hopu, hōʻeha ʻana i ka hanu, nā arrhythmias cardiac a me ka palaualelo mahele. Mai kahi ʻano lāʻau lapaʻau, ʻike ʻia nā samandarins e lilo i mea kūlohelohe kūloko kūloko. Eia kekahi, loaʻa iā lākou ka hana antimicrobial.